Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2
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چکیده
منابع مشابه
Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2
The late endo-/lysosomal P-type ATPase ATP13A2 (PARK9) is implicated in Parkinson's disease (PD) and Kufor-Rakeb syndrome, early-onset atypical Parkinsonism. ATP13A2 interacts at the N-terminus with the signaling lipids phosphatidic acid (PA) and phosphatidylinositol (3,5) bisphosphate (PI(3,5)P2), which modulate ATP13A2 activity under cellular stress conditions. Here, we analyzed stable human ...
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ژورنال
عنوان ژورنال: Parkinson's Disease
سال: 2016
ISSN: 2090-8083,2042-0080
DOI: 10.1155/2016/9531917